Dose Matters
It's why masks and social distancing matter.
I told Gregg this and got him to start masking up while there was still (obscenely) word out there that masks were worthless. Non N95 masks aren't perfect, and even N95 masks don't provide perfect protection, because even skilled medical personnel may put them on incorrectly.
But maybe by wearing a mask you get a smaller shot of the virus if you're someplace where it's airborne.
This thinking is started to be echoed in various places.
Anne Hendershot writes in the American Spectator:
According to a report in the New York Times by Joshua Rabinowitz, a professor of chemistry and genomics, and Caroline Bartman, a genomic researcher, the importance of viral dose is being overlooked in discussions of the coronavirus: "As with any other poison, viruses are usually more dangerous in larger amounts. Small initial exposures tend to lead to mild or asymptomatic infections while larger doses can be lethal."This has policy implications. Working in an office building that once had someone with the coronavirus in it is not as dangerous as dancing with a coronavirus infected person in the streets of New Orleans for Mardi Gras or on the beaches during Spring Break. And neither are as dangerous as spending time around severely ill Coronavirus patients in an ICU ward. This helps us understand why young healthcare workers -- without underlying conditions -- are falling ill with the virus. Many of them are dying.
In China, more than 3,300 health care workers were infected including Dr. Li Wenliang who died after being the first to alert the world to the pandemic. More than 4,800 health care workers have been infected in Italy and as New York City's hospitals become ever more impacted, several ER physicians and other healthcare workers are reported to be in critical condition -- some health care workers have died. We have to protect healthcare workers with whatever they need and it seems that we are finally doing that.
But for the rest of us, it is time to think about the policy implications of the fact that dose matters. It is possible to return to work at the end of our 30 day confinement -- but with proper precautions including masks, hand-washing, and appropriate social distancing. Medical personnel will always face extreme risk and need to be protected. But, for the rest of us, risk-reduction measures should suffice -- including mandatory mask-wearing in congested cities like New York City. Considering the fact that "dose matters" can make all the difference.
New Yorkers discover in tragically hard ways that there is a cost to electing a Mayor who is sufficiently "woke" but insufficiently awake. https://t.co/wVXpq29V61
— Amy Alkon (@amyalkon) April 5, 2020








On Feb. 29, the U.S. Surgeon General tweeted:
Seriously people- STOP BUYING MASKS! They are NOT effective in preventing general public from catching #Coronavirus, but if healthcare providers can’t get them to care for sick patients, it puts them and our communities at risk!
I, and a lot of others, wondered why masks were not effective for the general public, but imperative for health care providers.
Kevin at April 4, 2020 11:15 PM
1. This is not a poison, it's a virus. Unless your "experts" can cogently describe how level of exposure effects infection levels - or the body's ability to respond to the virus - then this is garbage.
2. The "experts" are still undecided about how much casual airborne transmission there really is outside of close spaces. I posted here a video from a doctor in NYC's Weill-Cornell hospital who asserted that the primary value of masks is as a tactile cue to keep people from touching their faces.
Ben David at April 5, 2020 5:35 AM
"or on the beaches during Spring Break."
Please explain how salt and UV make a friendly place for any virus, such that the beach rates with other locations.
Some state, probably yours, is making the news for arresting a paddleboarder for being outside by himself, offshore. He was arrested, forced to spend time in the close company of others, then released to carry the virus home. The offense will be on the order of "failing to do what the State requires."
Do not believe that police will protect you in any case. They will do what is required of them by the State, just like the TSA -- which should be a brilliant warning.
Ben David - true, a virus is not a conventional poison. Poisons do not cause the body to make more poison. The greater the number of virus particles introduced to a body, the further along the multiplication cycle and the faster an immune system can be overwhelmed. This is elementary.
Radwaste at April 5, 2020 6:26 AM
From Crid's 'Dang Ben' series here are a number of good papers on masks and their effectiveness from a variety of years.
https://docs.google.com/document/d/1HLrm0pqBN_5bdyysOeoOBX4pt4oFDBhsC_jpblXpNtQ/edit#
There was a particularly good meta-analysis I got from Crid that covered this and a plausible reason why the CDC has been so opposed to masks. Unfortunately I can't put my hand on it. The argument boiled down to masks are somewhat effective in reducing transmission but are fairly ineffective at reducing reception. Not that they don't have an effect on reception but that the effect is relatively small. Well, due to decades of fighting off medical quackery the CDC and FDA have very hard limits in what they are willing to accept as 'real'. Unfortunately mask effectiveness falls under this line in the sand the two organizations have chosen. So they've been fighting against generalized mask use in the US for decades.
Ben at April 5, 2020 7:17 AM
I am always amused by some folks need to use scare quotes around the word experts.
They aren't "experts"... they are experts.
The reason the directives and information being released changes over time is that the experts are constantly learning new things.
This is what it is like to work in an area where things are poorly understood and being actively studied.
You should fully expect to see conflicting reports and tentative conclusions that are later disconfirmed.
Normally this kind of thing doesn't take place in the media, but this is par for the course in the early stages of an investigation.
Current CDC recommendation is to wear masks, so now we adapt to the new information.
Artemis at April 5, 2020 8:37 AM
I saw that NYT article last week. Since the discussions of “social distancing**” and wearing face masks began, I had wondered if the amount of the virus one was exposed to mattered. It seemed reasonable to me that it did.
The authors write:
If the evidence is, in fact, very compelling, then I wonder why it’s being ignored. Could it be that there is evidence, but it’s not as compelling as the authors maintain?
** I prefer “physical distancing.” Even prior to the internet and social media, one could be still be social, via the telephone, while not being physical.
JD at April 5, 2020 8:45 AM
“The reason the directives and information being released changes over time is that the experts are constantly learning new things.”
Artemis, I’m sure the experts have been learning new things about this particular Coronavirus but, based on what the authors wrote...
...it appears that dose sensitivity is one thing that is well known.
Regarding your comment about scare quotes, I’m sure that Holocaust deniers refer to “historians.”
JD at April 5, 2020 9:00 AM
*I* wish the media would stop being so constantly lazy. That is, they should say "doctors," not "experts." Same goes for any other situation where they have a few seconds to google and come up with the proper nouns instead of a pronoun.
It just might make ignorant, immature people think twice before trying to drag more educated/trained people down to their level.
Lenona at April 5, 2020 9:06 AM
Ben, there's another problem.
In theory, the CDC could have said "yes, go ahead and wear makeshift masks - to protect OTHER people, that is - but please don't BUY masks, because health workers are in desperate need of anything that's professionally made."
But...as many have pointed out by now, the wearing of makeshift masks would give too many people a false sense of confidence, maybe even to the point of going outdoors or to the store too often. So they could end up catching it and passing it along, all before they have any symptoms.
Lenona at April 5, 2020 9:20 AM
JD,
It is well understood that viral load is an important feature in contagion.
What has recently been discovered is that unlike the flu which is spread by droplets (which are still small), COVID-19 appears to be spread by aerosolized particles in the breath (which are *much* smaller).
This means that unlike the flu, COVID-19 can be transmitted via a conversation just from the breath even in the absence of a sneeze or cough.
Artemis at April 5, 2020 9:49 AM
Lenona, the CDC policy on mask is decades old. This isn't a new thing with them. It long predates the current virus. The policy was not put in place due to current supply shortages.
JD, the evidence on viral dose isn't compelling. It is complicated. It is known that small doses have little effect and large doses can have large effect. But where the dividing line sits is pretty much unknown. Some animal testing has been done. But for understandable ethical concerns there is very little data on humans.
Also this isn't about learning new things. You can look at the list of papers on masks I linked. They go back over 20 years.
Ben at April 5, 2020 9:55 AM
Ben,
This conversation is in fact about learning new things precisely because it is in response to comments made by Ben David:
"The "experts" are still undecided about how much casual airborne transmission there really is outside of close spaces."
We are in fact still learning about the most important factors in the transmission and spread of COVID-19. Particularly when it comes to asymptomatic transmission (i.e., transmission when the infected person does not sneeze or cough).
This aspect of asymptomatic transmission of particular importance here when the evidence suggests that many infected folks do not display obvious signs of illness.
Artemis at April 5, 2020 10:47 AM
Artemis, from articles I’ve read recently, it appears that what you mentioned is true: this this virus ca spread via aerosols as well as droplets. However, in an article I just read in The Scientist, it says this:
But then there’s this:
JD at April 5, 2020 10:57 AM
JD,
This goes back to what I was saying before:
"You should fully expect to see conflicting reports and tentative conclusions that are later disconfirmed.
Normally this kind of thing doesn't take place in the media, but this is par for the course in the early stages of an investigation."
Normally what happens is this kind of thing is all hashed out in the literature and in conferences where science and medical experts weigh in and continue to study until a general consensus has been established.
What you are observing is how the early stages of research plays out in real time. Everything you hear is going to be tentative and subject to revision.
At this stage of the game things are going to look like a moving target as new data comes in.
Artemis at April 5, 2020 11:03 AM
From a March 31 article in The NYT, other support for “dosage matters”:
JD at April 5, 2020 11:08 AM
Arty, There is new stuff about this specific disease. As for the efficacy of masks, no, there is very little new information there. The issue with asymptomatic but infectious people is not a new one. What we are learning is how prevalent that issue is with this disease.
The CDC's choice to change it's stance on generalized mask usage isn't one based on science but instead based on politics. I am glad they have finally changed their recommendations. But I also recognize why they changed them. It is a pity they didn't do this 50 years ago.
Ben at April 5, 2020 11:23 AM
Ben,
I am glad you have decided that none of the research coming out about this specific disease is new... might I recommend that you alert the research community that is devoting substantial resources to researching a topic you have decided is already resolved.
www.ncbi.nlm.nih.gov/pubmed/32171189
www.nejm.org/doi/full/10.1056/nejmc2004973
link.springer.com/article/10.1631/jzus.B2010010
www.preprints.org/manuscript/202002.0283/v1
That is just a VERY small sampling of the research reports that are being published or having pre-prints made available.
Please do yourself a favor and stop asserting something is known here and that none of what we are talking about is new information for this disease when that is exactly what is going on right now.
Artemis at April 5, 2020 4:02 PM
You still need to work on your reading comprehension Arty.
"There is new stuff about this specific disease." ~Ben
Might want to tone the insults down a bit too.
Ben at April 5, 2020 5:21 PM
Ben,
You see insults where none exist.
What you are saying if factually incorrect.
If someone points out that you have said something that is wrong that isn't an insult.
When you say we aren't learning new things about this specific disease you are spreading misinformation.
In fact I see you spreading lots of misinformation regarding COVID-19 on this forum. Please stop.
Artemis at April 5, 2020 6:14 PM
Just to clarify because I want to avoid confusion I am specifically talking about mask use... we are in fact learning new things about mask use. That decision is NOT primarily political as you are asserting.
Artemis at April 5, 2020 6:17 PM
You are wrong Arty. Please stop spreading misinformation. And insults too.
Ben at April 5, 2020 7:31 PM
Ben,
If someone points out you are mistaken that isn't an insult.
Someone telling you to refrain from spreading misinformation isn't an insult either.
Since you insist that we are learning nothing new with regard to mask use and COVID-19 I will simply point out the following.
Back on March 20th the following article was published in The Lancet:
www.thelancet.com/journals/lanres/article/PIIS2213-2600(20)30134-X/fulltext?fbclid=IwAR3jPgQVbLpRJl1ooq4T2Z8gkeSQh0k0NzABKrXSEP5FPyfts-o66LGwxc0
"Despite the consistency in the recommendation that symptomatic individuals and those in health-care settings should use face masks, discrepancies were observed in the general public and community settings."
In other words, the literature isn't yet consistent on the use of masks by the general public and use in community settings.
It isn't a settled issue yet.
The fact you keep speaking about this subject as if it is settled and there is some kind of scientific consensus is incorrect.
We are in fact learning about best practices here and the use of masks in public settings isn't simply a political decision as you keep asserting.
The fact that we are learning that COVID-19 aerosolizes even amongst asymptomatic infected persons changes the calculus as well.
This is an area of active investigation. Please stop acting like this is settled and known.
Artemis at April 5, 2020 7:45 PM
Arty, you just demonstrated unquestionably your inability to read. Most people cause in such an obvious error might take a step back. Reassess things. Figure out how they could be so obviously wrong. But not you. Instead it is full speed ahead. You may be going in the wrong direction but by god you will get there faster. Lord knows this isn't a one off error. Instead it is normal for you.
So I say again, please stop spreading misinformation and work on your insulting behavior too.
Ben at April 6, 2020 6:02 AM
Ben,
This is what you said regarding masks verbatim:
"Also this isn't about learning new things. You can look at the list of papers on masks I linked."
The reference I provided to you has 8 separate references from March of this year regarding different mask related policies based on different learnings on how to handle COVID-19.
I didn't imagine that you said this isn't about learning new things with regard to mask use during this pandemic... it is what you explicitly said.
If you would like to correct or amend your previous statement you are welcome to do so, but I am addressing an actual statement you made.
Artemis at April 6, 2020 8:40 AM
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